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1

Apoptosis-Inducing Factor: Structure, Function, and Redox Regulation

Sevrioukova, Irina F.

Journal:

Antioxidants & Redox Signaling

Year:

2011

Language:

english

File:

PDF, 1.37 MB

english, 2011

2

Redox reactions of the FAD-containing apoptosis-inducing factor (AIF) with quinoidal xenobiotics: A mechanistic study

Lina Misevičienė, Žilvinas Anusevičius, Jonas Šarlauskas, Irina F. Sevrioukova, Narimantas Čėnas

Journal:

Archives of Biochemistry and Biophysics

Year:

2011

Language:

english

File:

PDF, 315 KB

english, 2011

3

Severe X-linked mitochondrial encephalomyopathy associated with a mutation in Apoptosis Inducing Factor 1

Daniele Ghezzi⁎, Irina Sevrioukova, Federica Invernizzi, Costanza Lamperti, Marina Mora, Pio D'Adamo, Francesca Novara, Orsetta Zuffardi, Graziella Uziel, Massimo Zeviani

Journal:

Year:

2011

Language:

english

File:

PDF, 63 KB

english, 2011

4

Structure-based inhibitor design for evaluation of a CYP3A4 pharmacophore model

Kaur, Parminder, Chamberlin, Richard, Poulos, Thomas L., Sevrioukova, Irina F.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 2.29 MB

english, 2015

5

Analysis of the myoglobin gene in heart disease

Eduardo Fernandez, Angie Duke, Irina Sevrioukova, Ralph V. Shohet

Journal:

Year:

1997

Language:

english

File:

PDF, 178 KB

english, 1997

6

Severe X-Linked Mitochondrial Encephalomyopathy Associated with a Mutation in Apoptosis-Inducing Factor

Daniele Ghezzi, Irina Sevrioukova, Federica Invernizzi, Costanza Lamperti, Marina Mora, Pio D'Adamo, Francesca Novara, Orsetta Zuffardi, Graziella Uziel, Massimo Zeviani

Journal:

The American Journal of Human Genetics

Year:

2010

Language:

english

File:

PDF, 1.42 MB

english, 2010

7

Understanding the mechanism of cytochrome P450 3A4: recent advances and remaining problems

Sevrioukova, Irina F., Poulos, Thomas L.

Journal:

Dalton Transactions

Year:

2013

Language:

english

File:

PDF, 2.20 MB

english, 2013

8

Reconstitution of the Fatty Acid Hydroxylase Activity of Cytochrome P450BM-3 Utilizing Its Functional Domains

Irina Sevrioukova, Gilles Truan, Julian A. Peterson

Journal:

Archives of Biochemistry and Biophysics

Year:

1997

Language:

english

File:

PDF, 281 KB

english, 1997

9

Structural biology of redox partner interactions in P450cam monooxygenase: A fresh look at an old system

Irina F. Sevrioukova, Thomas L. Poulos

Journal:

Archives of Biochemistry and Biophysics

Year:

2011

Language:

english

File:

PDF, 1.58 MB

english, 2011

10

Interaction of human cytochrome P4503A4 with ritonavir analogs

Irina F. Sevrioukova, Thomas L. Poulos

Journal:

Archives of Biochemistry and Biophysics

Year:

2012

Language:

english

File:

PDF, 1.32 MB

english, 2012

11

Crystal Structure of Putidaredoxin, the [2Fe–2S] Component of the P450cam Monooxygenase System from Pseudomonas putida

Irina F. Sevrioukova, Carlos Garcia, Huiying Li, B. Bhaskar, Thomas L. Poulos

Journal:

Journal of Molecular Biology

Year:

2003

Language:

english

File:

PDF, 2.23 MB

english, 2003

12

Crystal Structure of Putidaredoxin Reductase from Pseudomonas putida, the Final Structural Component of the Cytochrome P450cam Monooxygenase

Irina F. Sevrioukova, Huiying Li, Thomas L. Poulos

Journal:

Journal of Molecular Biology

Year:

2004

Language:

english

File:

PDF, 2.77 MB

english, 2004

13

Redox-dependent Structural Reorganization in Putidaredoxin, a Vertebrate-type [2Fe-2S] Ferredoxin from Pseudomonas putida

Irina F. Sevrioukova

Journal:

Journal of Molecular Biology

Year:

2005

Language:

english

File:

PDF, 665 KB

english, 2005

14

Redox-Linked Conformational Dynamics in Apoptosis-Inducing Factor

Irina F. Sevrioukova

Journal:

Journal of Molecular Biology

Year:

2009

Language:

english

File:

PDF, 3.21 MB

english, 2009

15

P450BM-3: A tale of two domains—or is it three?

Julian A. Peterson, Irina Sevrioukova, Gilles Truan, Sandra E. Graham-Lorence

Journal:

Year:

1997

Language:

english

File:

PDF, 824 KB

english, 1997

16

The FMN-Binding Domain of Cytochrome P450BM-3: Resolution, Reconstitution, and Flavin Analogue Substitution †

Haines, Donovan C., Sevrioukova, Irina F., Peterson, Julian A.

Journal:

Year:

2000

Language:

english

File:

PDF, 134 KB

english, 2000

17

Electron transfer in the ruthenated heme domain of cytochrome P450BM-3

Irina F. Sevrioukova, Chad E. Immoos, Thomas L. Poulos, Patric Farmer

Journal:

Israel Journal of Chemistry

Year:

2000

Language:

english

File:

PDF, 1.08 MB

english, 2000

18

Pyridine-Substituted Desoxyritonavir Is a More Potent Inhibitor of Cytochrome P450 3A4 than Ritonavir

Sevrioukova, Irina F., Poulos, Thomas L.

Journal:

Journal of Medicinal Chemistry

Year:

2013

Language:

english

File:

PDF, 1.91 MB

english, 2013

19

Dissecting Cytochrome P450 3A4–Ligand Interactions Using Ritonavir Analogues

Sevrioukova, Irina F., Poulos, Thomas L.

Journal:

Year:

2013

Language:

english

File:

PDF, 577 KB

english, 2013

20

Equilibrium and Transient State Spectrophotometric Studies of the Mechanism of Reduction of the Flavoprotein Domain of P450BM-3 †

Sevrioukova, Irina, Shaffer, Catherine, Ballou, David P., Peterson, Julian A.

Journal:

Year:

1996

Language:

english

File:

PDF, 552 KB

english, 1996

21

Cowchock Syndrome Is Associated with a Mutation in Apoptosis-Inducing Factor

Rinaldi, Carlo, Grunseich, Christopher, Sevrioukova, Irina F., Schindler, Alice, Horkayne-Szakaly, Iren, Lamperti, Costanza, Landouré, Guida, Kennerson, Marina L., Burnett, Barrington G., Bönnemann, C

Journal:

The American Journal of Human Genetics

Year:

2012

Language:

english

File:

PDF, 1.02 MB

english, 2012

22

Structure of a Cytochrome P450-Redox Partner Electron-Transfer Complex

Irina F. Sevrioukova, Huiying Li, Hong Zhang, Julian A. Peterson and Thomas L. Poulos

Journal:

Proceedings of the National Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.36 MB

english, 1999

23

Putidaredoxin-to-Cytochrome P450cam Electron Transfer: Differences between the Two Reductive Steps Required for Catalysis †

Kuznetsov, Vadim Yu., Poulos, Thomas L., Sevrioukova, Irina F.

Journal:

Year:

2006

Language:

english

File:

PDF, 358 KB

english, 2006

24

Production and Characterization of a Functional Putidaredoxin Reductase−Putidaredoxin Covalent Complex

Churbanova, Inna Y., Poulos, Thomas L., Sevrioukova, Irina F.

Journal:

Year:

2010

Language:

english

File:

PDF, 3.07 MB

english, 2010

25

Laser Flash Induced Electron Transfer in P450cam Monooxygenase: Putidaredoxin Reductase−Putidaredoxin Interaction †

Sevrioukova, Irina F., Hazzard, James T., Tollin, Gordon, Poulos, Thomas L.

Journal:

Year:

2001

Language:

english

File:

PDF, 104 KB

english, 2001

26

The Flavoprotein Domain of P450BM-3: Expression, Purification, and Properties of the Flavin Adenine Dinucleotide- and Flavin Mononucleotide-Binding Subdomains †

Sevrioukova, Irina, Truan, Gilles, Peterson, Julian A.

Journal:

Year:

1996

Language:

english

File:

PDF, 342 KB

english, 1996

27

Arginines 65 and 310 in Putidaredoxin Reductase Are Critical for Interaction with Putidaredoxin

Sevrioukova, Irina F., Poulos, Thomas L.

Journal:

Year:

2010

Language:

english

File:

PDF, 3.48 MB

english, 2010

28

Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase

Mukherjee, Paramita, Li, Huiying, Sevrioukova, Irina, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.

Journal:

Journal of Medicinal Chemistry

Year:

2015

Language:

english

File:

PDF, 3.70 MB

english, 2015

29

Anion-Dependent Stimulation of CYP3A4 Monooxygenase

Sevrioukova, Irina F., Poulos, Thomas L.

Journal:

Year:

2015

Language:

english

File:

PDF, 2.48 MB

english, 2015

30

Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir

Irina F. Sevrioukova, Thomas L. Poulos and Harry B. Gray

Journal:

Proceedings of the National Academy of Sciences

Year:

2010

Language:

english

File:

PDF, 1.39 MB

english, 2010

31

Structure/Function Relations in AIFM1 Variants Associated with Neurodegenerative Disorders

Sevrioukova, Irina F.

Journal:

Journal of Molecular Biology

Year:

2016

Language:

english

File:

PDF, 2.22 MB

english, 2016

32

Key Role of the Adenylate Moiety and Integrity of the Adenylate-Binding Site for the NAD + /H Binding to Mitochondrial Apoptosis-Inducing Factor

Sorrentino, Luca, Calogero, Alessandra Maria, Pandini, Vittorio, Vanoni, Maria Antonietta, Sevrioukova, Irina F., Aliverti, Alessandro

Journal:

Year:

2015

Language:

english

File:

PDF, 2.63 MB

english, 2015

33

Structural basis for regiospecific midazolam oxidation by human cytochrome P450 3A4

Sevrioukova, Irina F., Poulos, Thomas L.

Journal:

Proceedings of the National Academy of Sciences

Year:

2017

Language:

english

File:

PDF, 1.59 MB

english, 2017

34

High-Level Production and Properties of the Cysteine-Depleted Cytochrome P450 3A4

Sevrioukova, Irina F.

Journal:

Year:

2017

Language:

english

File:

PDF, 6.92 MB

english, 2017

35

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Zhijun, Sevrioukova, Irina F., Denisov, Ilia G., Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G., Hanse, Eric A., Cuellar, Rebecca A.D., Grinkova, Yelena V., Langenfeld, Vanessa Wankhede, Swedien,

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 4.94 MB

english, 2017

36

Heme Binding Biguanides Target Cytochrome P450-Dependent Cancer Cell Mitochondria

Guo, Zhijun, Sevrioukova, Irina F., Denisov, Ilia G., Zhang, Xia, Chiu, Ting-Lan, Thomas, Dafydd G., Hanse, Eric A., Cuellar, Rebecca A.D., Grinkova, Yelena V., Langenfeld, Vanessa Wankhede, Swedien,

Journal:

Cell Chemical Biology

Year:

2017

Language:

english

File:

PDF, 172 KB

english, 2017

37

Inhibition of Human CYP3A4 by Rationally Designed Ritonavir-Like Compounds: Impact and Interplay of the Side Group Functionalities

Samuels, Eric R., Sevrioukova, Irina

Journal:

Molecular Pharmaceutics

Year:

2017

Language:

english

File:

PDF, 7.04 MB

english, 2017

38

Direct Synthesis of α-Thio Aromatic Acids from Aromatic Amino Acids

Samuels, Eric R., Sevrioukova, Irina

Journal:

Tetrahedron Letters

Year:

2018

Language:

english

File:

PDF, 796 KB

english, 2018

39

Steroid bioconjugation to a CYP3A4 allosteric site and its effect on substrate binding and coupling efficiency

Polic, Vanja, Sevrioukova, Irina F., Auclair, Karine

Journal:

Archives of Biochemistry and Biophysics

Year:

2018

Language:

english

File:

PDF, 1.61 MB

english, 2018

40

Interaction of Human Drug-Metabolizing CYP3A4 with Small Inhibitory Molecules

Sevrioukova, Irina

Journal:

Year:

2019

File:

PDF, 3.90 MB

2019

41

Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-hydroxylation is an In Vitro Marker of CYP3A7 Activity

Chen, Yu-Jie, Zhang, Jian, Zhu, Ping-Ping, Tan, Xian-Wen, Lin, Qiu-Hong, Wang, Wen-Xia, Yin, Shan-Shan, Gao, Ling-Zhi, Su, Ming-Ming, Liu, Chang-Xiao, Xu, Liang, Jia, Wei, Sevrioukova, Irina F., Lan,

Journal:

Drug Metabolism and Disposition

Year:

2019

File:

PDF, 1.45 MB

2019

42

Structure-activity relationships of rationally designed ritonavir analogs: Impact of side-group stereochemistry, head-group spacing, and backbone composition on the interaction with CYP3A4

Samuels, Eric R., Sevrioukova, Irina

Journal:

Year:

2019

Language:

english

File:

PDF, 974 KB

english, 2019

43

Stereoselective Oxidation Kinetics of Deoxycholate in Recombinant and Microsomal CYP3A Enzymes: Deoxycholate 19-hydroxylation is an In Vitro Marker of CYP3A7 Activity

Chen, Yu-Jie, Zhang, Jian, Zhu, Ping-Ping, Tan, Xian-Wen, Lin, Qiu-Hong, Wang, Wen-Xia, Yin, Shan-Shan, Gao, Ling-Zhi, Su, Ming-Ming, Liu, Chang-Xiao, Xu, Liang, Jia, Wei, Sevrioukova, Irina F., Lan,

Journal:

Drug Metabolism and Disposition

Year:

2019

Language:

english

File:

PDF, 1.45 MB

english, 2019

44

Conformational Response of N-Terminally Truncated Cytochrome P450 3A4 to Ligand Binding in Solution

Chuo, Shih-Wei, Liou, Shu-Hao, Wang, Lee-Ping, Britt, R. David, Poulos, Thomas L., Sevrioukova, Irina, Goodin, David B.

Journal:

Year:

2019

File:

PDF, 2 KB

2019

45

Structural Insights into the Interaction of Cytochrome P450 3A4 with Suicide Substrates: Mibefradil, Azamulin and 6′,7′-Dihydroxybergamottin

Sevrioukova, Irina F.

Journal:

International Journal of Molecular Sciences

Year:

2019

Language:

english

File:

PDF, 1.59 MB

english, 2019

46

Unexpected Differences Between Two Closely Related Bacterial P450 Camphor Monooxygenases

Murarka, Vidhi C., Batabyal, Dipanwita, Amaya, Jose A., Sevrioukova, Irina, Poulos, Thomas L.

Journal:

Year:

2020

File:

PDF, 728 KB

2020

47

An increase in side-group hydrophobicity largely improves the potency of ritonavir-like inhibitors of CYP3A4

Samuels, Eric R., Sevrioukova, Irina F.

Journal:

Bioorganic & Medicinal Chemistry

Year:

2020

File:

PDF, 6.28 MB

2020

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